ANTENA: Artificial Intelligence to render the best clinical trial design for a novel RNA-based therapy for heart failure 

Stemming from the collaborative efforts of Summa and HORAIZON, a leading expert in biomedical analytics and AI model generation, we are developing the AI ANTENA platform to support clinical trial enrichment and biomarker verification to identify the best study population for the RNA-based therapies currently developed by Summa. The AI ANTENA platform will be an invaluable tool to help biopharma companies select the best study population from large datasets and will fit seamlessly within the Health and Care application area of the Dutch AI Coalition (NL AIC). 

ANTENA is a collaborative project funded by the Netherlands Enterprise Agency under the MIT-R&D-Artificiële intelligentie (AI) 2023 agreement n° MIT-AI-23-03471399.

CAESAR: ​Multicellular 3D cardiac models to accelerate drug discovery and development for ischemic heart disease

Collaborative Eurostars project of 2 million Euro awarded to accelerate the development of novel RNA therapeutics that elicit cardiac regeneration using advanced heart tissue models made from multiple types of cardiac cells. Through a collaborative partnership with Myriamed, we are developing multicellular 3-dimensional cardiac tissue models that help us test the efficacy of our innovative RNA-based therapies. These models incorporate human-induced pluripotent stem cell-derived cardiomyocytes, endothelial cells, and fibroblasts which are formed into Engineered Heart Muscles. Designed to reproduce human heart disease pathophysiology, the models provide a more accurate and ethical alternative to animal testing for studying disease progression and evaluating therapeutic compounds. Throughout the CAESAR project, these models will be utilized to advance the development of our RNA-based therapies, evaluate the effectiveness of innovative viral vectors for enhanced delivery efficiency, and drive progress in our drug discovery pipeline.

Eurostars is an international funding program co-financed by the European Union through Horizon Europe. It aims to boost innovation in small and medium-sized enterprises (SMEs) across Europe by fostering collaboration among EU countries and facilitating the development of unique products for the market. The CAESAR project is funded by the Eurostars Programme under the project ID 6184.